Winstrol, and aging of the liver

Stanozolol is a derivative of DHT, or dihydrotestosterone. It is considered to be a building center that slowly builds muscle mass and builds strength. Unfortunately, as with all the best means, there are considerable spillover effects. First of all, stanozolol is one of the most destructive agents for the blood lipid profile. 

According to studies by Thompson PD et al. Administration of 6 mg stanazolol per day, for 6 weeks caused a decrease in HDL cholesterol by 33%, and HDL-2 fraction by 71%! 

Recently, researchers have tested how high doses of winstrol affect the liver. It’s not that winstrol is hepatotoxic, because we’ve known it for decades. The abuse of winstrol may result in the onset of adenomas and rarely liver cancer (HCC; hepatocellular carcinoma). What has been proven in a newer experiment? 

The rats were divided into groups 

Stanozolol and its metabolites, 16-β-hydroxystanozolol and 3′-hydroxystanazole, were detected in rat liver by liquid chromatography with mass spectrometry (LC-MS). Telomerase activity, which is involved in cell aging and tumor formation, was detected by studying reverse transcriptase (TERT) expression levels and a phosphatase and tensin homologue (PTEN) in stanozolol-treated rat liver. Stanozolol induced telomerase activity at the molecular level in rat liver tissue, and physical exercise (swimming) reversed this induction, reflecting the possible premature aging of liver tissue. The expression of the PTEN gene in rat liver was practically unaffected by either physical exercise or administration of stanozolol. 

Increased telomerase activity is found in 90% of human tumors and 80% of hepatocellular carcinomas. Most healthy cells do not show telomerase activity. 

The conclusion is that, most likely, a high dose of 5 mg / kg of winstrol along with physical exercise accelerates the aging of liver cells. 

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You can read also: Boldenone and winstrol have a strong effect on fertility