Trivia about Viagra

 

Once, scientists led by Melinda SheffieldMoore checked whether the famous PDE5 (PDE = phosphodiesterase) inhibitor has an effect on muscle protein synthesis. Viagra is a type 5 phosphodiesterase inhibitor and has an effect after approximately 27 minutes and lasts for 4 hours. Phosphodiesterase 5 inhibitors increase the NO (nitric oxide) response by inhibiting cyclic GMP degradation. 

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Nitric oxide increases the anabolic response to insulin and amino acids in older people, it also seems to be indispensable for hypertrophy in mice, it has an effect on muscle regeneration. The decrease in the activity of signal pathways mediated by nitric oxide is associated with a decrease in muscle performance. Most likely, it is one of the processes associated with aging and debilitation and occurring at Becker or Duchenne muscular dystrophy. It is easy to get tired in mice with impaired NO production. 

Viagra is used to treat erectile dysfunction, but it does not work in every man because there are various causes of sexual dysfunctions, some of them for example at the atherosclerotic background. Recently, researchers described the case of a 31-year-old man who complained of photopsy, i.e. strong light impressions referred to as flashes and erythropsia (red vision). Anyway, in the leaflet of the sildenafil containing product, color vision disturbances have been defined as chloropsy (vision in green), chromatopsis, cyanopsy (vision in blue), erythropsia (red vision), xanthopsia (vision in yellow). 

In a man (using electroretinogram, optical coherence tomography, etc.), photoreceptor damage that lasted several months was found. Conclusion Sildenafil citrate in higher doses can lead to phenomena toxic to retina. This is worrying, as lead is harmful for sight (or rather, nobody voluntarily wants to have contact with lead, but after viagra it reaches many men). Viagra in pre-diabetic patients (25 mg, 3x / day) increased insulin sensitivity after 3 months. In animals large (I would even say that cosmic, equivalent to 26.6 mg / kg body weight) viagra dose causes adverse metabolic disorders (insulin resistance, increase in glucose). Does Viagra work thermogenically? This has not been reported, even when administering gigantic doses of type 5 phosphodiesterase inhibitor.