The hormonal system works on the basis of feedback. Delivery of exogenous substances such as anabolic-androgenic steroids (eg testosterone enanthate, sustanon / omnadren, DHT derivatives eg masteron, winstrol) or thyroid hormones (eg T3) affects the production of endogenous hormones (testosterone in the testes, T4 / T3 in thyroid).
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Regarding the thyroid, the administration of e.g. synthetic T3 has an inhibitory effect on TSH in the hypothalamus (thyroline, prothrelin) and in the pituitary gland (TSH, thyrotropin hormone, thyrotropin).
Unfortunately, it was not possible to develop a preparation that would affect the testosterone concentration without inhibiting the production of endogenous testosterone in the testes. Even SARMs have a greater or lesser impact on LH and testosterone production.
The Scott Griffiths et al 2 study investigated how SAA users perceive PCT (post-cycle therapy). The persons using SAA, hCG, growth hormone, beta mimetics (eg clenbuterol), SERM preparations (eg tamoxifen), insulin and peptides were taken into account.
It turned out that access to funds used in post-cycle therapy is not easy. SAA users treat agents used during PCT (eg hCG, HMG, tamoxifen, clomid) as necessary to maintain increments and health. PCT is of great importance for mental health. Often, men had easier access to SAA than to hCG or tamoxifen, so they reluctantly set aside SAA (not to lose weight and strength).
However, such a procedure can have many side effects. When it comes to mental health, numerous studies indicate that after discontinuation of SAA mood disorders may appear and in some people more serious disorders.
Pope and Katz showed that 23% of patients abusing SAA meet the DSM-III criteria for mood disorders, from major depressive disorders to bipolar I and II disorders. In part, it is related to the perception of one’s own image.
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