Nandrolone, and nitric oxide and endothelial dysfunction

Nandrolone has many negative side effects, including may affect the cardiovascular system. There are dozens of reports that relatively mild nandrolone caused fibrosis, congestion and inflammation of kidneys of rabbits. Not only that, nandrolone in doses of 4 and 10 mg per kilogram of body weight, twice a week for 6 months, caused fibrosis and inflammatory infiltration of the heart. 

However, it usually happened after a very high dose of Nandrolone for many months. More recently, scientists have learned how nandrolone can affect endothelium-dependent vasodilatation factor, which is nitric oxide (NO). Loss of endothelium dependent NO activity is typical for early atherosclerosis, promotes smooth muscle contraction in the wall of blood vessels, increases thromboembolism, activates the inflammatory process and promotes changes in vaso-muscular cells. 

In the Guzzoni V. et al experiment, placebo or nandrolone rats were given to rats, some animals were trained, while others were not. Nandrolone was used at a dose of 5 mg / kg body weight, 2x a week. The amount of nitric oxide formed and reactive oxygen species were evaluated using DAF-2 methods and hydroethidine fluorescence techniques. 


Conclusions: high doses of Nandrolone lower the bioavailability of nitric oxide and may induce endothelial dysfunction and morphological changes in the arteries. It is not known whether such changes occur in humans, but it can be expected – for now we are waiting for further research in this matter. 


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