Heparegen, and the liver

Heparegen is an interesting prescription preparation that affects liver regeneration. In studies by R. Farbiszewski et al 1, it was checked how the drug would affect superoxide dismutase (SOD), CAT, GSH-Px. Superoxide dismutase (SOD) is an antioxidant enzyme. GSH-Px is glutathione peroxidase, while CAT is catalase. CAT catalyzes the oxidation reaction of ethanol, methanol, formate, nitrites, quinones and other compounds.

Lowering catalase activity accompanies many diseases, including pneumonia, tuberculosis, atherosclerosis, diabetes, jaundice, cancer, neurodegenerative diseases (Parkinson’s disease, Alzheimer’s disease), nephritis and others. Very extensive information on this subject. The rats were treated with Timonacic (Thiazolidine-4-carboxylic acid) for 7, 14 or 21 days after alcoholic liver injury. It has been found that thiazolidine carboxylic acid has an effect on the activity of glutathione peroxidase, to some extent also affects superoxide dismutase and catalase. 

After 21 days of drug administration, the enzyme activity was restored. In addition, heparegen reduced the time needed to restore normal ALAT (alanine aminotransferase) and GGTP (gamma-glutamyltransferase) values. These enzymes are used to diagnose liver damage (GGTP activity also increases, eg after a heart attack). GGTP is the most sensitive liver enzyme in the detection of biliary obstruction, cholangitis or cholecystitis. 3 An isolated increase in GGTP activity is typical of alcoholic liver damage.


Heparegen may be a useful preparation for people abusing alcohol and probably also SAA (bodybuilders). 


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