Glucosamine for joint pain and injuries

One of the most important tasks in the process of regeneration of the articular cartilage is fulfilled by glucosamine sulphate. 

Osteoarthritis is most often the result of biological and mechanical disturbances that destabilize the processes of destruction and renewal of joint cartilage and subchondral bone layer. This process can be initiated by various factors, the most popular and the most dangerous is the untreated injury. It quickly covers all joint tissues. It is characterized by pain, tenderness and limitation of mobility. The prolongation of the average life expectancy causes the growing medical and social problem which is the degenerative disease. Currently, it is the most common cause of disability and incapacity to work. In addition to cardiovascular and neoplastic diseases, it is the most difficult medical and medical dilemma to solve. The development of motoring, the popularisation of sport and the negative impact of the external environment on the development of children and youth caused not only an increase in the number of injuries, but also increased their severity with the subsequent formation of post-traumatic degenerative changes. The disease usually affects knee and hip joints, spine and wrist joints. For our needs, we have accepted the division into primary and secondary degenerative disease. Primary occurs without a clear cause, secondary is the result of an injury or other accompanying disease. 

The essence of the development of the disease is the disturbance of the balance between regeneration and disintegration of cartilage, spontaneous or as a result of injuries and diseases. When the regenerative capacity of the joint cartilage is exceeded, damage occurs with the subsequent occurrence of osteoarthritis. 

One of the most important tasks in the process of regeneration of the articular cartilage is fulfilled by glucosamine sulphate. It is a substrate for the synthesis of proteoglycans contained in the basic substance of joint cartilage. The supply of glucosamine sulphate from the outside stimulates the biosynthesis of proteoglycans, which is disturbed in osteoarthritis. The stimulation of proteoglycan synthesis exerts a beneficial effect on cartilage trophism and facilitates the synthesis of chondroitiniar acid, which counteracts cartilage degeneration. 

Under natural conditions, glucosamine is produced by cartilage cells from glucose and glutamine. Glucosamine sulphate is a glucosamine monosaccharide compound synthesized from chitin. As a chemically pure substance, it is well absorbed from the stomach and intestines. In addition, it blocks the action of cartilage-distributing enzymes and has anti-inflammatory effects. 

 

In clinical studies conducted with the use of glucosamine sulphate, it was found that after 2 weeks of use in an oral dose of 1500 mg, pain in the knee joints and the spine decreased. During the 3-month application, the preparation was more effective in treating the symptoms of post-traumatic osteoarthritis than some non-steroidal anti-inflammatory drugs. Glucosamine sulphate is the only preparation that alleviates the symptoms of degenerative disease and slows down the rate of joint damage. This means the ability of the agent to modify the course of the disease. Scientific reports place particular emphasis on the low efficacy of glucosamine hydrochloride used as an ingredient in some formulations available on the market. 

 

The proposed simultaneous administration of glucosamine sulphate and chondroitin did not find any scientific justification. High levels of glucosamine sulphate and high levels of chondroitiniariaric acid simultaneously inhibit and stimulate proteoglycan synthesis. Chemical interference in subsequent stages of the same metabolic pathway may lead to imbalance and secondary inhibition of articular cartilage renewal. 

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