Does nandrolone affect homocysteine ​​levels?

Anabolic steroids can affect the absorption of vitamins B6 and B12 – and thus can lead to an increase in the level of homocysteine.

Why?

Homocysteine ​​metabolism also depends on 2 vitamins B6 and B12 as cofactors. This explains why taking SAA can increase the level of homocysteine. 

Researchers checked whether nandrolone decanoate had an effect on homocysteine ​​levels in rats. They were given a gigantic dose of 3 and 10 mg / kg body weight nandrolone decanoate by weekly intramuscular injections. Animals from the control group received a solvent from nandrolone decanoate. After 14 weeks, the total plasma homocysteine ​​level was measured. In order to ascertain the adequacy of doses and the bioavailability of nandrolone, testicular parameters were also studied. While the functions of the nuclei were significantly suppressed, no relationship was found between the administration of nandrolone decanoate and the total homocysteine ​​concentration. Thus, factors other than plasma homocysteine ​​levels may contribute to an increased incidence of cardiovascular events following chronic use of anabolic-androgenic steroids. 

Nandrolone does not have to cause hyperhomocysteinemia – however, it has other, proven negative effects on the human system (including the structure of collagen fibers).

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