Antidepressants a source of overweight and obesity?

Obesity causes a number of serious diseases, certainly increases the chances of cardiovascular diseases, cancer, diabetes, metabolic disorders, etc. Between 1975 and 2014 global obesity rates increase from 3.2% to 10.8% for men and 6.4% to 14.9% for women . 


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Recently conducted by Rafael Gafoor, Helen P. Booth and Martin C. Gulliford 1, the study sheds alarming light on the effect of using antidepressants on body weight. The observations were carried out for 10 years on 136 762 men and 157 957 women. Of this, in the first year of observation, antidepressants in the surveillance group began to use 13.0% men and 22.4% women (17,803 men and 35,307 women in middle-aged 51.5 years). 

The risk of increasing body weight (at least by 5%) for people who did not use antidepressants was 8.1 per 100 person-years, while those taking similar drugs showed a 21% higher risk of weight gain. Overall, the estimated risk of weight gain (in terms of BMI) in the second year of use was 29% higher (from normal weight to overweight or obesity) and practically the same for people who were already overweight when taking drugs and gained extra kilos during treatment causing obesity. 

This does not mean that there is a cause-and-effect link between taking anti-depressants and increasing body weight. The researchers emphasize that similar correlations may result from a systematic error related to the uneven distribution of disruptive factors in the surveyed groups (residual confounding). 

You probably need more research to prove a clear cause and effect relationship, but people who use antidepressants should exercise caution.